Joint Fellowship Training Program Fellows Sarah Kennett, Ph.D. Phone:   (301) 827-0617 E-Mail:   Sarah.Kennett@fda.hhs.gov Professional Background</p> Dr. Kennett received her Ph.D. in Molecular Cancer Biology from Duke University and did post-doctoral training in the Laboratory of Molecular Carcinogenesis at the National Institutes of Health/National Institute of Environmental Health Sciences. She began the NCI-FDA Oncology Product Research/Review Fellowship program in September 2005. Research Interests Dr. Kennett's research background encompasses multiple aspects of cancer biology. As a graduate student, she studied control of the cell cycle via regulation of transcription by the Rb and Sp transcription factor families. Her Interest in cancer research and therapeutic target identification and a desire for a broader experience led her to pursue post-doctoral training in a signal transduction laboratory where she identified molecules important for the adhesion steps of the metastatic cascade and examined the mechanisms for their regulation. Dr. Kennett's continuing interests in therapeutic agents and the aspiration to use her experience and skills to help efficiently and safely move the best potential therapeutics through the pipeline to patients led her to the NCI-FDA fellowship, where in addition to regulatory work, she is examining methods for increasing immune cells' anti-tumor capacities. Fellowship Experiences "I believe the key experience that the NCI-FDA fellowship has provided for me is that of working as an unofficial reviewer in FDA's Division of Cellular, Tissue, and Gene Therapies. I have had the opportunity to be heavily involved in the product review of INDs that have come through the Division, which has been an excellent hands-on learning experience. In addition, attending both in-house and FDA-sponsored meetings has allowed me to learn about common product issues and how they might be handled and to take part in discussion and development of FDA policy. The NCI-FDA fellowship has also given me the opportunity to study product regulation from industry's perspective by allowing me to attend training courses offered by the DIA and FDLI, in supplement to FDA-sponsored training, which have further broadened my understanding of regulatory affairs." Career Goals "I am eager to begin a career that will make use of the experience and skills I have obtained and honed during my research tenure and as an NCI-FDA Fellow to bring about the effective transition of therapeutics from the research lab to the consumer. "

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